Iran fired a new wave of missile attacks on Israel early Monday, triggering air raid sirens across the country as emergency services reported at least three killed and dozens more wounded in the fourth day of open warfare between the regional foes that showed no sign of slowing.

Iran announced it had launched some 100 missiles and vowed further retaliation for Israel's surprise attack on its nuclear program and military leadership, which has killed at least 224 since it began last Friday.

Israel said that in response its fighter jets had struck 10 command centers in Tehran belonging to Iran's Quds Force, an elite arm of its Revolutionary Guard that conducts military and intelligence operations outside Iran.

Powerful explosions, likely from Israel’s defense systems intercepting Iranian missiles, rocked Tel Aviv shortly before dawn on Monday, sending plumes of black smoke into the sky over the coastal city.

Authorities in the central Israeli city of Petah Tikva near Tel Aviv said that Iranian missiles had hit a residential building there, charring concrete walls, shattering windows and heavily damaging multiple apartments.

The Israeli Magen David Adom emergency service reported that two women and one man — all in their 70s — were killed in the wave of missile attacks that struck four sites in central Israel. That brought the total death toll in Israel to at least 17 since Iran began striking at the country in response to Israel’s sweeping attacks on its military and nuclear infrastructure.

“We clearly see that our civilians are being targeted,” said Israeli police spokesman Dean Elsdunne outside the bombed-out building in Petah Tikva. “And this is just one scene, we have other sites like this near the coast, in the south.”

The MDA added that paramedics had evacuated another 74 wounded people to hospitals, including a 30-year-old woman in serious condition, while rescuers were still searching for residents trapped beneath the rubble of their homes.

“When we arrived at the scene of the rocket strike, we saw massive destruction,” said Dr. Gal Rosen, a paramedic with MDA who said he had rescued a 4-day-old baby as fires blazed from the building.

Iranian Foreign Minister Abbas Araghchi said Sunday that Iran will stop its strikes if Israel does the same.

But after a day of intensive Israeli aerial attacks that extended targets beyond military installations to hit oil refineries and government buildings, the Revolutionary Guard struck a hard line, vowing that further rounds of strikes would be “more forceful, severe, precise and destructive than previous ones."

Health authorities also reported that 1,277 were wounded in Iran, without distinguishing between military officials and civilians.

Rights groups, like the Washington-based Iranian advocacy group called Human Rights Activists, have suggested that the Iranian government’s death toll is a significant undercount. Human Rights Activists says it has documented more than 400 people killed, among them 197 civilians.

Israel argues that its attack was necessary to stop Iran from obtaining a nuclear weapon.

Iran has always said its nuclear program was peaceful, and the U.S. and others have assessed that it has not pursued a nuclear weapon since 2003.

But Iran has enriched ever-larger stockpiles of uranium to near weapons-grade levels in recent years and was believed to have the capacity to develop multiple weapons within months if it chose to do so.